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Meg Ryan has published a heartfelt tribute to the late filmmaker Rob Reiner, under whose direction she worked in the beloved rom-com When Harry Met Sally.

A Heartbreaking Event

Reiner was found dead with his wife, Michele Singer Reiner, at their Los Angeles home over the weekend.

“We will miss this man so deeply…” Ryan shared on Instagram, alongside a picture of them together. “We thank you, Rob and Michele, for your belief in true love, fairy tales, and laughter. We appreciate your faith in human goodness and your deep patriotism.”

Legal Proceedings Unfold

Reiner’s son Nick, 32, is accused of two counts of first-degree murder and was in court today. He’s being incarcerated with no bail set. Reports indicate that Reiner’s daughter Romy discovered her father deceased.

“I have to believe that their story will not end with this impossible tragedy, that some good may come, some awareness raised,” Ryan added. “Perhaps they would desire a legacy of hope and humanity, leading us toward empathy and tranquility.”

A Statement from Siblings

Reiner’s other children Jake and Romy released a message today. “No words can convey the constant, profound sorrow we feel,” they said. “Losing our parents in such a horrific way is a devastation beyond comprehension. They weren’t just our parents; they were our best friends.”

Peers Pay Their Respects

Ryan’s co-star, Billy Crystal, joined in remembering Reiner via comments shared yesterday together with remarks by Larry David, Martin Short and Albert Brooks.

“No one matched his comic instinct, his dedication to rhythmic dialogue, or his elegant sharpening of drama,” the tribute noted. “He cherished performers and improved scribes. Freedom was his key offering. He listened to ideas and included you in the creative journey. Everyone felt like part of a crew. His direction was a gift, but his legacy is broader.”

A Storied Career

When Harry Met Sally was a box office and critical triumph in 1989, grossing more than $93 million worldwide and earning Nora Ephron an Oscar nomination for best original screenplay.

Rob Reiner first encountered Michele Singer Reiner whilst filming When Harry Met Sally. The pair were introduced by Barry Sonnenfeld, a fellow filmmaker and pal.

Reiner’s notable filmography also included classics such as Misery, Stand by Me and The Princess Bride. The director and his wife were married for 36 years.